现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • PF-04449613
PF-04449613的可视化放大

PF-04449613

A PDE9A inhibitor

原价
¥325-5862
价格
260-4690
PF-04449613的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx23258
  • CAS: 1236858-52-8
  • 别名:
  • 分子式: C21H25N5O3
  • 分子量: 395.5
  • 纯度: >98%
  • 溶解度: DMSO: 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50 = 22 nM).1 It is selective for PDE9A over PDE1C (IC50 = >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 µM but does inhibit the human dopamine transporter (DAT; Ki = 293 nM). PF-04449613 (0.1-100 mg/kg, s.c.) increases cerebrospinal fluid (CSF) levels of cyclic GMP (cGMP) in rats. Subcutaneous administration of PF-04449613 (10 mg/kg) increases the rate of dendritic spine formation and elimination in mouse primary motor cortex pyramidal neurons in vivo.2 It increases the average running speed of mice in an accelerating rotarod task, indicating improved motor learning, at the same dose.



1.Claffey, M.M., Helal, C.J., Verhoest, P.R., et al.Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitorsJ. Med. Chem.55(21)9055-9068(2012) 2.Lai, B., Li, M., Hu, A., et al.The phosphodiesterase 9 inhibitor PF-04449613 promotes dendritic spine formation and performance improvement after motor learningDev. Neurobiol.78(9)859-872(2018)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服