PPACK (trifluoroacetate salt)

An antithrombin peptide

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥600.00

480.00

- +
5mg

￥2537.00

2030.00

- +
10mg

￥4475.00

3580.00

- +
25mg

￥10437.00

8350.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx23288
CAS: N/A
别名: Pebac, DPhenylalanylprolylarginyl Chloromethyl Ketone
分子式: C21H31ClN6O3.XCF3COOH
分子量: 451
纯度: >98%
溶解度: DMF: 33 mg/ml,DMSO: 33 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 5 mg/ml
储存: Store at -20°C
库存: 现货

Background

PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (K_i = 0.24 nM).^1,2,3 It has been used as an anticoagulant (100 μM) and to study thrombin-mediated fibrin deposition, angiogenesis, and proinflammatory processes.^4,5

1.Kovach, I.M., Kelley, P., Eddy, C., et al.Proton bridging in the interactions of thrombin with small inhibitorsBiochemistry48(30)7296-7304(2009) 2.Bode, W., Turk, D., and Karshikov, A.The refined 1.9-? x-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationshipsProtein Science1(4)426-471(1992) 3.Hanson, S.R., and Harker, L.A.Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketoneProceedings of the National Academy of Sciences of the United States of America85(9)3184-3488(1988) 4.Lyon, M.E., Fine, J.S., Henderson, P.J., et al.D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK): Alternative anticoagulant to heparin salts for blood gas and electrolyte specimensClinical Chemistry41(7)1038-1041(1995) 5.Liu, J.F., Hou, S.M., Tsai, C.H., et al.Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathwaysArthritis Research & Therapy14(2)R91(2012)