PRGL493

An ACSL4 inhibitor

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库存: 现货

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包装

价格

促销价

数量
5mg

￥512.00

410.00

- +
10mg

￥1000.00

800.00

- +
50mg

￥4362.00

3490.00

- +
100mg

￥8212.00

6570.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).¹ It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 µM. PRGL493 (5 µM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.

1.Castillo, A.F., Orlando, U.D., Maloberti, P.M., et al.New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesisCell. Mol. Life Sci.(2020)