Prostaglandin D2-d4

An internal standard for the quantification of prostaglandin D2

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货号: ajcx23328
CAS: 211105-29-2
别名: PGD2-d4
分子式: C20H28D4O5
分子量: 356.5
纯度: ＞98%
溶解度: DMF: ＞100 mg/ml (from PGD2),DMSO: ＞50 mg/ml (from PGD2),Ethanol: ＞75 mg/ml (from PGD2),PBS pH 7.2: ＞5 mg/ml (from PGD2)
储存: Store at -20°C
库存: 现货

Background

Prostaglandin D₂-d₄ (PGD₂-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGD₂ by GC- or LC-mass spectrometry. PGD₂ is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD₂ is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.2,3 In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD₂ inhibits human ovarian tumor cell proliferation with an IC₅₀ of 6.8 µM.

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生命科学

有机化学

无机化学

材料科学

Prostaglandin D2-d4

Prostaglandin D2-d4详情

Background

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