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  • Prostaglandin F2α-1-glyceryl ester-d5
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Prostaglandin F2α-1-glyceryl ester-d5

A neuropeptide with diverse biological activities

原价
¥1012-12950
价格
810-10360
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  • 货号: ajcx23350
  • CAS: N/A
  • 别名: PGF2α1glyceryl esterd5
  • 分子式: C23H35D5O7
  • 分子量: 433.6
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 500 μg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Prostaglandin F-1-glyceryl ester-d5 (PGF-1-glyceryl ester-d5) contains five deuterium atoms. It is intended for use as an internal standard for the quantification of PGF-1-glyceryl ester by GC- or LC-MS. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the central cannabinoid receptor.1,2 Incubation of 2-AG with cyclooxygenase 2 and specific PGH2 isomerases in cell cultures and isolated enzyme preparations results in PG glyceryl ester formation.3 The biosynthesis of PGH, PGD, PGE, PGF, and thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of PGF-1-glyceryl ester has been investigated, little is known about its intrinsic biological activity.4



1.Sugiura, T., Kodaka, T., Kondo, S., et al.2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma X glioma hybrid NG108-15 cellsBiochemical and Biophysical Research Communications22958-64(1996) 2.Sugiura, T., Kodaka, T., Kondo, S., et al.Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cellsJ. Biochem.122(4)890-895(1997) 3.Kozak, K.R., Crews, B.C., Morrow, J.D., et al.Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamidesJ. Biol. Chem.277(47)44877-44885(2002) 4.Kozak, K.R., Crews, B.C., Ray, J.L., et al.Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivoThe Journal of Biological Chemisty276(40)36993-36998(2001)

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