Prostaglandin F2α-d4

An internal standard for the quantification of prostaglandin F2α

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货号: ajcx23352
CAS: 34210-11-2
别名: Prostaglandin F2a-d4; PGF2α-d4
分子式: C20H30D4O5
分子量: 358.5
纯度: >98%
溶解度: 10 mM Na2CO3: >6.5 mg/ml (from PGF2a),DMF: >100 mg/ml (from PGF2a),DMSO: >100 mg/ml (from PGF2a),Ethanol: >100 mg/ml (from PGF2a),PBS pH 7.2: >10 mg/ml (from PGF2a)
储存: Store at -20°C
库存: 现货

Background

Prostaglandin F_2α-d₄ (PGF_2α-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF_2α by GC- or LC-mass spectrometry. PGF_2α is a widely distributed prostaglandin occurring in many species.^1,2,3 It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exerts potent luteolytic activity.¹ PGF_2α exhibits its receptor mediated physiological activity at 50-100 nM.¹ Maximal ovine myometrial contraction can be achieved at 125 nM PGF_2α in vitro.⁴

1.Samuelsson, B., Goldyne, M., Granstr?m, E., et al.Prostaglandins and thromboxanesAnnu. Rev. Biochem.47997-1029(1978) 2.Speroff, L., and Ramwell, P.W.Prostaglandins in reproductive physiologyAm. J. Obstet. Gynecol.107(7)1111-1130(1970) 3.Watanabe, K., Iguchi, Y., Iguchi, S., et al.Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9α,-11β,15-trihydroxyprosta-5,13-dien-1-oic acid (9α,11β-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2α by bovine lung prostaglandin F synthaseProc. Natl. Acad. Sci. U.S.A.83(6)1583-1587(1986) 4.Crankshaw, D.J., and Gaspar, V.Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewesJ. Reprod. Fertil.103(1)55-61(1995)