- 首页
- TNF Receptor
- Raloxifene-d4 (hydrochloride)
Raloxifene-d4 (hydrochloride)
An internal standard for the quantification of raloxifene
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
500ug￥1625.001300.00- +
-
1mg￥3112.002490.00- +
-
5mg￥13662.0010930.00- +
- 货号: ajcx23388
- CAS: 1188263-47-9
- 别名: 雷洛昔芬-D4,盐酸盐
- 分子式: C28H23D4NO4S.HCl
- 分子量: 514.1
- 纯度: ＞98%
- 溶解度:
- 储存: Store at 2°C to 8°C
- 库存: 现货
Background
Raloxifene-d4 is intended for use as an internal standard for the quantification of raloxifene by GC- or LC-MS. Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits estrogenic activity in bone cells without stimulating breast or uterine tissues.1 Raloxifene guards endothelial cells obtained from rat aortic rings against oxidative insult (1 µM) and lowers serum cholesterol in ovariectomized rodents (ED50 = 0.2 mg/kg).2,1 Formulations containing raloxifene have been shown to reduce bone resorption and promote bone formation in post-menopausal women.3
1.Black, L.J., Sato, M., Rowley, E.R., et al.Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized ratsJ. Clin. Invest.93(1)63-69(1994) 2.Wong, C.M., Yung, L.M., Leung, F.P., et al.Raloxifene protects endothelial cell function against oxidative stressBr. J. Pharmac.155(3)326-334(2008) 3.?zmen, B., Kirmaz, C., Aydin, K., et al.Influence of the selective oestrogen receptor modulator (raloxifene hydrochloride) on IL-6, TNF-α, TGF-?1 and bone turnover markers in the treatment of postmenopausal osteoporosisEur. Cyto. Netw.18(3)148-153(2007)
