RC363

An inhibitor of ferroptosis

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库存: 现货

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1mg

￥712.00

570.00

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5mg

￥3262.00

2610.00

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10mg

￥5737.00

4590.00

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货号: ajcx23400
CAS: 2584411-86-7
别名:
分子式: C18H24OS2
分子量: 320.5
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): insouble,PBS (pH 7.2): insouble
储存: Store at -20°C
库存: 现货

Background

RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .¹ It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a concentration of 25 µM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC₅₀ = 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT22 cells when used at a concentration of 3 µM. RC363 inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells (IC₅₀ = 173.6 nM).

1.Bueno, D.C., Canto, R.F.S., de Souza, V., et al.New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cellsMol. Neurobiol.57(8)3273-3290(2020)