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  • RC574
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RC574

An inhibitor of ferroptosis

原价
¥937-6000
价格
750-4800
RC574的二维码

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  • 货号: ajcx23402
  • CAS: 2584411-87-8
  • 别名:
  • 分子式: C18H24OSSe
  • 分子量: 367.4
  • 纯度: >98%
  • 溶解度: DMF: 20 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1 It inhibits glutamate-induced cell death in HT22 cells (IC50 = 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells when used at concentrations ranging from 62.5 to 1,000 nM.



1.Bueno, D.C., Canto, R.F.S., de Souza, V., et al.New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cellsMol. Neurobiol.57(8)3273-3290(2020)

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