RC574

An inhibitor of ferroptosis

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库存: 现货

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1mg

￥937.00

750.00

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5mg

￥3500.00

2800.00

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10mg

￥6000.00

4800.00

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货号: ajcx23402
CAS: 2584411-87-8
别名:
分子式: C18H24OSSe
分子量: 367.4
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存: Store at -20°C
库存: 现货

Background

RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .¹ It inhibits glutamate-induced cell death in HT22 cells (IC₅₀ = 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells when used at concentrations ranging from 62.5 to 1,000 nM.

1.Bueno, D.C., Canto, R.F.S., de Souza, V., et al.New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cellsMol. Neurobiol.57(8)3273-3290(2020)