Rilpivirine-d6 (hydrochloride)

A neuropeptide with diverse biological activities

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库存: 现货

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500ug

￥3625.00

2900.00

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1mg

￥6462.00

5170.00

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Background

Rilpivirine-d₆ is intended for use as an internal standard for the quantification of rilpivirine by GC- or LC-MS. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC₅₀ value of 0.51 nM.¹ It is active against NNRTI-resistant HIV strains with EC₅₀ values of less than 1 nM for L100I, K103N, V106A, G190A, and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates (EC₅₀s = <10 nM), including strains containing up to eight resistance mutations. In vivo, rilpivirine, when used in combination with cabotegravir, lamivudine , and abcavir, reduces the plasma viral titer in HIV-1 infected humanized mice.²

1.Garvey, L., and Winston, A.Rilpivirine: A novel non-nucleoside reverse transcriptase inhibitorExpert Opin. Drug Discov.18(7)1035-1041(2009) 2.Arainga, M., Edagwa, B., Mosley, R.L., et al.A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapyRetrovirology14(1)17(2017)