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- RIP kinase
- SB-431542 (hydrate)
SB-431542 (hydrate)
Inhibitor of receptors ALK4, ALK5, and ALK7
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥512.00410.00- +
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5mg￥1425.001140.00- +
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10mg￥2062.001650.00- +
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25mg￥4500.003600.00- +
- 货号: ajcx23460
- CAS: N/A
- 别名:
- 分子式: C22H16N4O3.XH2O
- 分子量: 384.4
- 纯度: ＞98%
- 溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 2 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
SB-431542 is a potent and selective inhibitor of the TGF-
1.Callahan, J.F., Burgess, J.L., Fornwald, J.A., et al.Identification of novel inhibitors of the transforming growth factor ?1 (TGF-?1) type 1 receptor (ALK5)Journal of Medicinal Chemistry45(5)999-1001(2002) 2.Laping, N.J., Grygielko, E., Mathur, A., et al.Inhibition of Transforming Growth Factor (TGF)-?1-Induced Extracellular Matrix with a Novel Inhibitor of the TGF-? Type I Receptor Kinase Activity: SB-431542Molecular Pharmacology62(1)58-64(2002) 3.Inman, G.J., Nicolás, F.J., Callahan, J.F., et al.SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7Molecular Pharmacology62(1)65-74(2002) 4.James, D., Levine, A.J., Besser, D., et al.TGF?/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cellsDevelopment1321273-1282(2005) 5.Chambers, S.M., Fasano, C.A., Papapetrou, E.P., et al.Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingNature Biotechnology27(3)275-280(2009)
