A neuropeptide with diverse biological activities
sn-glycero-3-Phosphocholine-d9 is intended for use as an internal standard for the quantification of sn-glycero-3-phosphocholine by GC- or LC-MS. sn-glycero-3-Phosphocholine is a nootropic phospholipid, a precursor to choline biosynthesis, and an intermediate in the metabolism of phosphatidylcholine.1 In vivo, sn-glycero-3-phosphocholine is converted to phosphorylcholine, a metabolically active form of choline that increases acetylcholine synthesis and release in rat hippocampus. It prevents scopolamine-induced amnesia in a passive avoidance test in rats and exerts neuroprotective effects in models of altered cholinergic neurotransmission and models of brain vascular injury.1,2
1.Traini, E., Bramanti, V., and Amenta, F.Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent.Curr. Alzheimer Res.10(10)1070-1079(2013) 2.Sigala, S., Imperato, A., Rizzonelli, P., et al.L-α-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the ratEur. J. Pharmacol.211(3)351-358(1992)
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