An internal standard for the quantification of sphinganine (d18:0)
Sphinganine-d7 (d18:0) is intended for use as an internal standard for the quantification of sphinganine (d18:0) by GC- or LC-MS. Sphinganine (d18:0) is a precursor to ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate .1 Sphinganine (d18:0) levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers.2,3,4
1.Smith, E.R., and Merrill, A.H., Jr.Differential roles of de novo sphingolipid biosynthesis and turnover in the 'Burst' of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in cultureJ. Biol. Chem.270(32)18749-18758(1995) 2.Pruett, S.T., Bushnev, A., Hagedorn, K., et al.Biodiversity of sphingoid bases ("sphingosines") and related amino alcoholsJ. Lipid Res.49(8)1621-1639(2008) 3.Shephard, G.S., van der Westhuizen, L., and Sewram, V.Biomarkers of exposure to fumonisin mycotoxins: A reviewFood Addit. Contam.24(10)1196-1201(2007) 4.Yin, J., Miyazaki, K., Shaner, R.L., et al.Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markersFEBS Lett.584(9)1872-1878(2010)
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