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- PKD (Protein kinase D)
- Sphingosine-13C2-d2 (d18:1)
Sphingosine-13C2-d2 (d18:1)
A neuropeptide with diverse biological activities
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包装价格促销价数量
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1mg￥10237.008190.00- +
- 货号: ajcx23494
- CAS: N/A
- 别名: D-erythro-Sphingosine C18-13C2-d2
- 分子式: C16[13C]2H35D2NO2
- 分子量: 303.5
- 纯度: ＞98%
- 溶解度: Chloroform: soluble,Methanol: soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Sphingosine-13C2-d2 (d18:1) is intended for use as an analytical standard for the quantification of sphingosine (d18:1) by GC- or LC-MS. Sphingosine (d18:1) is formed primarily from the breakdown of ceramide.1 Sphingosine (d18:1) inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.1 Phosphorylation of sphingosine (d18:1) by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.2,3,4
1.Hannun, Y.A., Luberto, C., and Argraves, K.M.Enzymes of sphingolipid metabolism: From modular to integrative signalingBiochemistry40(16)4893-4903(2001) 2.Takuwa, Y., Takuwa, N., and Sugimoto, N.The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activitiesJ. Biochem.131(6)767-771(2002) 3.Ishii, I., Fukushima, N., Ye, X., et al.Lysophospholipid receptors: Signaling and biologyAnnu. Rev. Biochem.73321-354(2004) 4.Kluk, M.J., and Hla, T.Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptorsBiochim. Biophys. Acta1582(1-3)72-80(2002)
