Stearoyl-L-carnitine-d3 (chloride)

An internal standard for the quantification of stearoyl-L-carnitine

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库存: 现货

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500ug

￥1012.00

810.00

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1mg

￥1925.00

1540.00

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5mg

￥4525.00

3620.00

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货号: ajcx23530
CAS: 2245711-27-5
别名: CAR 18:0-d3, C18:0 Carnitine-d3, L-Carnitine octdecanoyl ester-d3, L-Carnitine stearoyl ester-d3, L-Octadecanoylcarnitine-d3, Octadecanoyl-L-carnitine-d3, L-Stearoylcarnitine-d3, R
分子式: C25H47D3NO4.Cl
分子量: 467.1
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 14 mg/ml,Ethanol: 20 mg/ml
储存: Store at -20°C
库存: 现货

Background

Stearoyl-L-carnitine-d₃ (chloride) is intended for use as an internal standard for the quantification of stearoyl-L-carnitine by GC- or LC-MS. Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine.¹ It inhibits sodium-dependent [³H]carnitine uptake in human proximal convoluted tubular (HPCT) cells by 52% when used at a concentration of 500 μM.² It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 µM.³ Plasma levels of stearoyl-L-carnitine are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease.^4,1

1.Reuter, S.E., Evans, A.M., Faull, R.J., et al.Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal diseaseAnn. Clin. Biochem.42(Pt 5)387-393(2005) 2.Huang, W., Shaikh, S.N., Ganapathy, M.E., et al.Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cellsBiochem. Pharmacol.58(8)1361-1370(1999) 3.Bell, F.P.Carnitine esters: Novel inhibitors of plasma lecithin: Cholesterol acyltransferase in experimental animals but not in man (Homo sapiens)Int. J. Biochem.15(2)133-136(1983) 4.Reuter, S.E., and Evans, A.M.Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activityJ. Intern. Med.270(1)76-84(2011)