An internal standard for the quantification of taurocholic acid
Taurocholic acid-d4 (TCA-d4) is intended for use as an internal standard for the quantification of TCA by GC- or LC-MS. TCA is a taurine-conjugated form of the primary bile acid cholic acid .1 Serum levels of TCA are decreased in patients with Crohn's disease and those with ulcerative colitis with no extraintestinal manifestations, but are increased in patients with ulcerative colitis accompanied by hepatobiliary disease.2
1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Gnewuch, C., Liebisch, G., Langmann, T., et al.Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel diseaseWorld J. Gastroenterol.15(25)3134-3141(2009)
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