Taurolithocholic Acid-d5 (sodium salt)

Taurolithocholic acid-d5 (TLCA-d5) is intended for use as an internal standard for the quantification of TLCA by GC- or LC-MS

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1mg

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Background

Taurolithocholic acid-d₅ (TLCA-d₅) is intended for use as an internal standard for the quantification of TLCA by GC- or LC-MS. TLCA is a taurine-conjugated form of the secondary bile acid lithocholic acid .¹ TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.² It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.^3,4 Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.¹

1.Schmid, A., Neumann, H., Karrasch, T., et al.Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS)PLoS One11(2)e0148869(2016) 2.Rust, C., Wild, N., Bernt, C., et al.Bile acid-induced apoptosis in hepatocytes is caspase-6-dependentJ. Biol. Chem.284(5)2908-2916(2009) 3.Denk, G.U., Maitz, S., Wimmer, R., et al.Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liverHepatology52(5)1758-1768(2010) 4.Javitt, N.B.Cholestasis in rats induced by taurolithocholateNature210(5042)1262-1263(1966)