现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Taurolithocholic Acid-d5 (sodium salt)
Taurolithocholic Acid-d5 (sodium salt)的可视化放大

Taurolithocholic Acid-d5 (sodium salt)

Taurolithocholic acid-d5 (TLCA-d5) is intended for use as an internal standard for the quantification of TLCA by GC- or LC-MS

原价
¥5437-5437
价格
4350-4350
Taurolithocholic Acid-d5 (sodium salt)的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx23564
  • CAS: 1265476-97-8
  • 别名:
  • 分子式: C26H39D5NO5S.Na
  • 分子量: 510.7
  • 纯度: >98%
  • 溶解度: Methanol: slightly soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Taurolithocholic acid-d5 (TLCA-d5) is intended for use as an internal standard for the quantification of TLCA by GC- or LC-MS. TLCA is a taurine-conjugated form of the secondary bile acid lithocholic acid .1 TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.2 It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.3,4 Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.1



1.Schmid, A., Neumann, H., Karrasch, T., et al.Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS)PLoS One11(2)e0148869(2016) 2.Rust, C., Wild, N., Bernt, C., et al.Bile acid-induced apoptosis in hepatocytes is caspase-6-dependentJ. Biol. Chem.284(5)2908-2916(2009) 3.Denk, G.U., Maitz, S., Wimmer, R., et al.Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liverHepatology52(5)1758-1768(2010) 4.Javitt, N.B.Cholestasis in rats induced by taurolithocholateNature210(5042)1262-1263(1966)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服