Telaprevir-d4

A neuropeptide with diverse biological activities

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库存: 现货

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250ug

￥11812.00

9450.00

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Background

Telaprevir-d₄ is intended for use as an internal standard for the quantification of telaprevir by GC- or LC-MS. Telaprevir is an inhibitor of hepatitis C virus (HCV) nonstructural protease 3/4A (NS3/4A; K_i = 7 nM).¹ It inhibits viral replication in genotype 1b HCV replicon cells and isolated human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC₅₀s = 354 and 280 nM, respectively). Telaprevir (10-300 mg/kg) reduces plasma levels of a secreted placental alkaline phosphatase (SEAP) reporter gene in a mouse model of HCV NS3/4A protease activity. Formulations containing telaprevir have been used in the treatment of HCV.

1.Perni, R.B., Almquist, S.J., Byrn, R.A., et al.Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine proteaseAntimicrob. Agents Chemother.50(3)899-909(2006)