现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Terbinafine-d3 (hydrochloride)
Terbinafine-d3 (hydrochloride)的可视化放大

Terbinafine-d3 (hydrochloride)

An internal standard for the quantification of terbinafine

原价
¥1437-11500
价格
1150-9200
Terbinafine-d3 (hydrochloride)的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx23578
  • CAS: 1310012-15-7
  • 别名: TDT 067-d3 hydrochloride
  • 分子式: C21H22D3N.HCl
  • 分子量: 330.9
  • 纯度: >98%
  • 溶解度: DMF: 14 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Terbinafine-d3 is intended for use as an internal standard for the quantification of terbinafine by GC- or LC-MS. Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. mentagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml).1 It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively).2 Terbinafine (90-120 µM) induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs).3,4 Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections.



1.Petranyi, G., Meingassner, J.G., and Mieth, H.Antifungal activity of the allylamine derivative terbinafine in vitroAntimicrob. Agents Chemother.31(9)1365-1368(1987) 2.Ryder, N.S., and Dupont, M.C.Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymesBiochem. J.230(3)765-770(1985) 3.Lee, W.S., Chen, R.J., Wang, Y.J., et al.In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrestInternational Journal of Cancer106125-137(2003) 4.Ho, P.Y., Liang, Y.C., Ho, Y.S., et al.Inhibition of human vascular endothelial cells proliferation by terbinafineInternational Journal of Cancer11151-59(2004)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服