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- GABA Receptor
- TFB-TBOA (hydrate)
TFB-TBOA (hydrate)
EAAT1 和 EAAT2 抑制剂
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥937.00750.00- +
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5mg￥3500.002800.00- +
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10mg￥5537.004430.00- +
- 货号: ajcx23586
- CAS: N/A
- 别名: CF3-Bza-TBOA
- 分子式: C19H17F3N2O6.XH2O
- 分子量: 426.3
- 纯度: ＞98%
- 溶解度: DMSO: 30 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
TFB-TBOA is an inhibitor of excitatory amino acid transporter 1 (EAAT1) and EAAT2 with IC50 values of 22 and 17 nM for EAAT1 and EAAT2, respectively, in a glutamate uptake assay using COS-1 cells.1 It is selective for EAAT1 and EAAT2 over EAAT3 (IC50 = 300 nM), as well as the choline, dopamine, GABA, norepinephrine, and serotonin transporters and a variety of neurotransmitter receptors at 10 µM. TFB-TBOA (10 µM) inhibits L-glutamate- and L-aspartate-induced currents in X. laevis oocytes. It induces convulsions in mice when administered at a dose of 0.2 µg/animal.
1.Shimamoto, K., Sakai, R., Takaoka, K., et al.Characterization of novel L-threo-β-benzyloxyaspartate derivatives, potent blockers of the glutamate transportersMol. Pharmacol.65(4)1008-1015(2004)
