TG11-77 (hydrochloride)

An EP2 receptor antagonist

原价

￥1550-9862

价格

￥ 1240-7890

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库存: 现货

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产品引用

货号: ajcx23588
CAS: 2550393-38-7
别名:
分子式: C23H24N6O.HCl
分子量: 436.9
纯度: >98%
溶解度: DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
储存: Store at -20°C
库存: 现货

Background

TG11-77 is a brain-permeable antagonist of the prostaglandin E₂ (PGE₂) receptor subtype EP₂ (K_B = 9.7 nM).¹ It is selective for EP₂ over DP₁, EP₄, and IP receptors (K_Bs = 7,320, 5,300, and >10,000 nM, respectively). TG11-77 (0.3 and 1 μM) inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP₂ receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP₂ receptors.

1.Amaradhi, R., Banik, A., Mohammed, S., et al.Potent, selective, water soluble, brain-permeable EP2 receptor antagonist for use in central nervous system disease modelsJ. Med. Chem.63(3)1032-1050(2020)

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生命科学

有机化学

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材料科学

TG11-77 (hydrochloride)

TG11-77 (hydrochloride)详情

Background