Trimethoprim-d3
An internal standard for the quantification of trimethoprim
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包装价格促销价数量
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500ug￥3000.002400.00- +
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1mg￥5662.004530.00- +
- 货号: ajcx23662
- CAS: 1189923-38-3
- 别名: 甲氧苄啶 D3
- 分子式: C14H15D3N4O3
- 分子量: 293.3
- 纯度: ＞98%
- 溶解度: DMSO: Slightly Soluble,Methanol: Slightly Soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Trimethoprim-d3 is intended for use as an internal standard for the quantification of trimethoprim by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid.1,2 Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).2 Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.
1.Lam, T., Hilgers, M.T., Cunningham, M.L., et al.Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolinesJ. Med. Chem.57(3)651-668(2014) 2.Schweitzer, B.I., Dicker, A.P., and Bertino, J.R.Dihydrofolate reductase as a therapeutic targetFASEB J.4(8)2441-2452(1990)
