Zanamivir-13C,15N2

An internal standard for the quantification of zanamivir

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Background

Zanamivir-¹³C,¹⁵N₂ is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.¹ It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC₅₀ values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC₅₀ values ranging from 0.6 to 7.9 nM in vitro. Intranasal zanamivir administration at 0.4 mg/kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza.

1.Elliott, M.Zanamivir: From drug design to the clinicPhilos. Trans. R. Soc. Lond. B Biol Sci.356(1416)1885-1893(2001)