α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

A peptide hormone

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥425.00

340.00

- +
5mg

￥2012.00

1610.00

- +
10mg

￥3887.00

3110.00

- +
25mg

￥8337.00

6670.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajcx23790
CAS: 171869-93-5
别名: Α-促黑激素,α-Melanocyte-Stimulating Hormone TFA
分子式: C77H109N21O19S.XCF3COOH
分子量: 1664.9
纯度: >98%
溶解度: DMF: 10mg/mL,DMSO: 25mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL
储存: Store at -20°C
库存: 现货

Background

α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.¹ It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC₅₀s = 0.16 and 56 nM, respectively).² α-MSH (100 pM) reduces S. aureus colony formation and C. albicans germ tube formation in vitro.³ It inhibits endotoxin-, ceramide-, TNF-α-, or okadaic acid-induced activation of NF-κB in U937 cells.¹ α-MSH reduces IL-6- or TNF-α-induced ear edema in mice.⁴ It also prevents the development of adjuvant-induced arthritis in rats and increases survival in a mouse model of septic shock. Increased plasma levels of α-MSH are positively correlated with delayed disease progression and reduced death in patients with HIV.¹

1.Catania, A., Airaghi, L., Colombo, G., et al.α-melanocyte-stimulating hormone in normal human physiology and disease statesTrends Endocrinol. Metab.11(8)304-308(2000) 2.Miwa, H., Gantz, I., Konda, Y., et al.Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptorsJ. Pharmacol. Exp. Ther.273(1)367-372(1995) 3.Cutuli, M., Cristiani, S., Lipton, J.M., et al.Antimicrobial effects of a-MSH peptidesJ. Leukoc. Biol.67(2)233-239(2000) 4.Lipton, J.M., Ceriani, G., Macaluso, A., et al.Antiiinflammatory effect of the neuropeptide a-MSH in acute, chronic, and systemic inflammationAnn. N.Y. Acad. Sci.25(741)137-148(1994)