An intermediate in GSH synthesis
γ-Glu-Cys is an intermediate in glutathione (GSH) synthesis.1 It is formed by ATP-dependent condensation of cysteine and glutamate by γ-glutamylcysteine synthetase. γ-Glu-Cys is also an essential component of phytochelatins, the heavy metal detoxifying enzymes in plants.2
1.Anderson, M.E., and Meister, A.Transport and direct utilization of γ-glutamylcyst(e)ine for glutathione synthesisProc. Natl. Acad. Sci. USA80(3)707-711(1983) 2.Grill, E., L?ffler, S., Winnacker, E.-L., et al.Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific γ-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase)Proc. Natl. Acad. Sci. USA86(18)6838-6842(1989)
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