A synthetic peptide substrate
RR-Src is a synthetic peptide substrate that corresponds to the sequence in Src surrounding the tyrosine subject to phosphorylation.1,2 It is a substrate for EGF-mediated tyrosine phosphorylation.3 RR-Src inhibits IL-2-induced proliferation of cytotoxic T cells.4
1.Casnellie, J.E., Harrison, M.L., Pike, L.J., et al.Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell lineProc. Natl. Acad. Sci. USA79(2)282-286(1982) 2.Pike, L.J., Gallis, B., Casnellie, J.E., et al.Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranesProc. Natl. Acad. Sci. USA79(5)1443-1447(1982) 3.Cassel, D., Pike, L.J., Grant, G.A., et al.Interaction of epidermal growth factor-dependent protein kinase with endogenous membrane proteins and soluble peptide substrateJ. Biol. Chem.258(5)2945-2950(1983) 4.Taffs, R.E., and Sitkovsky, M.V.Modulation of the effector functions of cytolytic T-lymphocytes with synthetic peptide inhibitors of protein kinasesJ. Pharm. Sci.81(1)37-44(1992)
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