A sphingolipid
Lyso-monosialoganglioside GM2 (Lyso-GM2) is a form of ganglioside GM2 that is lacking the fatty acyl group. Lyso-GM2 inhibits PKC in a cell-free assay (IC50 = 50 µM).1 Levels of lyso-GM2 are increased in the gray matter of postmortem brain samples from patients with Sandhoff disease or Tay-Sachs disease, as well as in a mouse model of Sandhoff disease.2,3 [Matreya, LLC. Catalog No. 1543]
1.Hannun, Y.A., and Bell, R.M.Lysosphingolipids inhibit protein kinase C: Implications for the sphingolipidosesScience235(4789)670-674(1987) 2.Kobayashi, T., Goto, I., Okada, S., et al.Accumulation of lysosphingolipids in tissues from patients with GM1 and GM2 gangliosidosesJ. Neurochem.59(4)1452-1458(1992) 3.Kodama, T., Togawa, T., Tsukimura, T., et al.Lyso-GM2 ganglioside: A possible biomarker of Tay-Sachs disease and Sandhoff diseasePLoS One6(12)e29074(2011)
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