Amycolatopsin C
A polyketide macrolide with antimycobacterial and anticancer activities
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100ug￥3212.002570.00- +
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500ug￥11937.009550.00- +
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- 货号: ajcx23874
- CAS: N/A
- 别名:
- 分子式: C47H76O17
- 分子量: 913.1
- 纯度: ＞98%
- 溶解度:
- 储存: -20°C
- 库存: 现货
Background
Amycolatopsin C is a polyketide macrolide originally isolated from Amycolatopsis that has antimycobacterial and anticancer activities.1 It is active against M. bovis and M. tuberculosis (IC50s = 2.7 and 5.7 µM, respectively) but not B. subtilis, S. aureus, E. coli, or P. aeruginosa (IC50s = >30 µM for all). Amycolatopsin C is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 10 and 5.9 µM, respectively).
1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494J. Antibiot. (Tokyo)70(12)1097-1103(2017)
