A peptide AT2 receptor agonist
Saralasin is a peptide angiotensin II type 2 (AT2) receptor agonist.1 It binds to AT2 receptors (Ki = 0.38 nM) and induces neurite outgrowth in NG108-15 cells when used at a concentration at 100 nM, an effect that can be inhibited by the AT2 receptor antagonist PD 123310. Saralasin (5 µg/animal, i.c.v.) enhances acquisition of the conditioned avoidance response in rats.2
1.Guimond, M.-O., Hallberg, M., Gallo-Payet, N., et al.Saralasin and sarile are AT2 receptor agonistsACS Med. Chem. Lett.5(10)1129-1132(2014) 2.Wright, J.W., and Harding, J.W.Brain angiotensin receptor subtypes AT1, AT2, and AT4 and their functionsRegul. Pept.59(3)269-295(1995)
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