Thymulin (acetate hydrate)

A peptide hormone

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库存: 现货

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1mg

￥575.00

460.00

- +
5mg

￥2012.00

1610.00

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10mg

￥3725.00

2980.00

- +
25mg

￥7900.00

6320.00

- +

已选 0 种 0 瓶

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货号: ajcx23890
CAS: N/A
别名: Thymic Factor
分子式: C33H54N12O15?XC2H4O2 [XH2O]
分子量: 858.9
纯度: >98%
溶解度: DMSO: slightly soluble,PBS (pH 7.2): 10 mg/ml
储存: -20°C
库存: 现货

Background

Thymulin is a zinc-dependent metallopeptide hormone with immunomodulatory, anti-inflammatory, and analgesic activities.^1,2 It is primarily produced by thymic epithelial cells but can be produced by macrophages and fibroblasts when exposed to extracellular stressors, such as heat or oxidative stress.² Thymulin potentiates mitogen-induced proliferation of IL-2 receptor-positive mature T cells.³ It reduces pro-inflammatory cytokine production in rodent models of LPS- or endotoxin-induced systemic inflammation, as well as prevents myocardial inflammation in a mouse model of encephalomyocarditis virus-induced myocarditis and suppresses autoantibody production in a mouse model of reovirus-induced thyroiditis.^4,5 Thymulin (0.1, 0.5, and 1 µg, i.c.v.) prevents endotoxin-induced hyperalgesia in rats.⁵

1.Bach, J.-F., and Dardenne, M.Thymulin, a zinc-dependent hormoneMed. Oncol. Tumor Pharmacother.6(1)25-29(1989) 2.Lunin, S.M., Khrenov, M.O., Glushkova, O.V., et al.Extrathymic production of thymulin induced by oxidative stress, heat shock, apoptosis, or necrosisInt. J. Immunopathol. Pharmacol.30(1)58-69(2017) 3.Hadden, J.W.Thymic endocrinologyAnn. N.Y. Acad. Sci.840(1)352-358(1998) 4.Santos, M.A.M., Henriques-Coelho, T., and Leite-Moreira, A.Immunomodulatory role of thymulin in lung diseasesExpert Opin. Ther. Targets14(2)131-141(2010) 5.Safieh-Garabedian, B., Ochoa-Chaar, C.I., Poole, S., et al.Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injectionNeuroscience121(4)865-873(2003)