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  • Thymulin (acetate hydrate)
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Thymulin (acetate hydrate)

A peptide hormone

原价
¥575-7900
价格
460-6320
Thymulin (acetate hydrate)的二维码

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  • 库存: 现货
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  • 货号: ajcx23890
  • CAS: N/A
  • 别名: Thymic Factor
  • 分子式: C33H54N12O15?XC2H4O2 [XH2O]
  • 分子量: 858.9
  • 纯度: >98%
  • 溶解度: DMSO: slightly soluble,PBS (pH 7.2): 10 mg/ml
  • 储存: -20°C
  • 库存: 现货

Background

Thymulin is a zinc-dependent metallopeptide hormone with immunomodulatory, anti-inflammatory, and analgesic activities.1,2 It is primarily produced by thymic epithelial cells but can be produced by macrophages and fibroblasts when exposed to extracellular stressors, such as heat or oxidative stress.2 Thymulin potentiates mitogen-induced proliferation of IL-2 receptor-positive mature T cells.3 It reduces pro-inflammatory cytokine production in rodent models of LPS- or endotoxin-induced systemic inflammation, as well as prevents myocardial inflammation in a mouse model of encephalomyocarditis virus-induced myocarditis and suppresses autoantibody production in a mouse model of reovirus-induced thyroiditis.4,5 Thymulin (0.1, 0.5, and 1 µg, i.c.v.) prevents endotoxin-induced hyperalgesia in rats.5



1.Bach, J.-F., and Dardenne, M.Thymulin, a zinc-dependent hormoneMed. Oncol. Tumor Pharmacother.6(1)25-29(1989) 2.Lunin, S.M., Khrenov, M.O., Glushkova, O.V., et al.Extrathymic production of thymulin induced by oxidative stress, heat shock, apoptosis, or necrosisInt. J. Immunopathol. Pharmacol.30(1)58-69(2017) 3.Hadden, J.W.Thymic endocrinologyAnn. N.Y. Acad. Sci.840(1)352-358(1998) 4.Santos, M.A.M., Henriques-Coelho, T., and Leite-Moreira, A.Immunomodulatory role of thymulin in lung diseasesExpert Opin. Ther. Targets14(2)131-141(2010) 5.Safieh-Garabedian, B., Ochoa-Chaar, C.I., Poole, S., et al.Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injectionNeuroscience121(4)865-873(2003)

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