DAPTA (acetate)

A CCR5 receptor antagonist

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库存: 现货

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包装

价格

促销价

数量
5mg

￥1212.00

970.00

- +
25mg

￥1950.00

1560.00

- +
50mg

￥6050.00

4840.00

- +
100mg

￥10900.00

8720.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx23892
CAS: N/A
别名: D-Ala-peptide T-amide
分子式: C35H56N10O15?XC2H4O2
分子量: 856.9
纯度: >98%
溶解度: DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
储存: -20°C
库存: 现货

Background

DAPTA is a peptide antagonist of chemokine (C-C motif) receptor 5 (CCR5).¹ It inhibits CD4-dependent binding of HIV-1_Ba-L and HIV-1_CM235 gp120 envelope proteins to CCR5 (IC₅₀s = 0.06 and 0.32 nM, respectively). DAPTA (0.1 mg/kg, i.p.) reduces marble burying and repetitive behavior, as well as decreases brain levels of IL-6, IL-9, and IL-17A, in the BTBR T⁺ Itpr3tf/J mouse model of autism spectrum disorder (ASD).² It also reduces LPS-induced microglial activation and astrocyte hypertrophy in the dentate gyrus in a rat model of chronic neuroinflammation.³

1.Polianova, M.T., Ruscetti, F.W., Pert, C.B., et al.Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA)Antiviral Res.67(2)83-92(2005) 2.Ahmad, S.F., Ansari, M.A., Nadeem, A., et al.DAPTA, a C-C chemokine receptor 5 (CCR5) antagonist attenuates immune aberrations by downregulating Th9/Th17 immune responses in BTBR T + Itpr3tf/J miceEur. J. Pharmacol.846100-108(2019) 3.Rosi, S., Pert, C.B., Ruff, M.R., et al.Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's diseaseNeuroscience134(2)671-676(2005)