Tunicamycin 16:1 Mixture

A mixture of tunicamycin 16:1 structural isomers

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库存: 现货

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1mg

￥1337.00

1070.00

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5mg

￥6000.00

4800.00

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10mg

￥10675.00

8540.00

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货号: ajcx23896
CAS: N/A
别名:
分子式: C39H64N4O16
分子量: 844.9
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存: -20°C
库存: 现货

Background

Tunicamycin 16:1 is a mixture of tunicamycin structural isomers that contain a 16-carbon N-acyl chain with variable branching patterns. The N-acyl chain incorporated into tunicamycins, like tunicamycin 16:1, is derived from the same pool of cellular branched-chain fatty acids (BCFAs) in Streptomyces and directly impacts the biological activity of each individual tunicamycin variant.^1,2,3 Purified tunicamycin 16:1 with the iso branching configuration inhibits bacterial phospho-MurNAc-pentapeptide transferase (MraY) with an IC₅₀ value of 0.11 µM.²

1.Price, N.P.J., Jackson, M.A., Hartman, T.M., et al.Branched chain lipid metabolism as a determinant of the N-Acyl variation of Streptomyces natural productsACS Chem. Biol.16(1)116-124(2021) 2.Hering, J., Dunevall, E., Snijder, A., et al.Exploring the active site of the antibacterial target MraY by modified tunicamycinsACS Chem Biol.15(11)2885-2895(2020) 3.Duksin, D., and Mahoney, W.C.Relationship of the structure and biological activity of the natural homologues of tunicamycinJ. Biol. Chem.257(6)3105-3109(1982)