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- WIN 66,306
WIN 66,306
A peptide antagonist of NK1 and NK2 receptors
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥4075.003260.00- +
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5mg￥16175.0012940.00- +
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- 货号: ajcx23912
- CAS: 151928-32-4
- 别名:
- 分子式: C41H52N8O9
- 分子量: 800.9
- 纯度: ＞98%
- 溶解度:
- 储存: -20°C
- 库存: 现货
Background
WIN 66,306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes.1 It binds to NK1 and NK2 receptors (Kis = 8 and 3.8 µM, respectively, for the human receptors) and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner.
1.Barrow, C.J., Doleman, M.S., Bobko, M.A., et al.Structure determination, pharmacological evaluation, and structure-activity studies of a new cyclic peptide substance P antagonist containing the new amino acid 3-prenyl-β-hydroxytyrosine, isolated from Aspergillus flavipesJ. Med. Chem.37(3)356-363(1994)
