A fluorescent probe for in vivo tumor cell imaging
IR 783 is a heptamethine cyanine fluorescent probe for in vivo imaging of tumor cells.1,2 It displays excitation/emission maxima of 633/780 nm, respectively. IR 783 is transported into tumor cells, an effect that can be blocked by the organic anion transporting polypeptide (OATP) inhibitor sulfobromophthalein .1 In vivo, IR 783 (11.25 mg/kg) preferentially accumulates in tumor tissue in an ACHN kidney cancer mouse xenograft model.2 It has been conjugated to polyethylenimines for tumor-specific gene delivery.3
1.Yuan, J., Yi, X., Yan, F., et al.Near?infrared fluorescence imaging of prostate cancer using heptamethine carbocyanine dyesMol. Med. Rep.11(2)821-828(2015) 2.Yang, X., Shao, C., Wang, R., et al.Optical imaging of kidney cancer with novel near-infrared heptamethine carbocyanine fluorescent dyesJ. Urol.189(2)702-710(2013) 3.De Los Reyes-Berbel, E., Salto-Gonzalez, R., Ortega-Mu?oz, M., et al.PEI-NIR heptamethine cyanine nanotheranostics for tumor targeted gene deliveryBioconjug. Chem.29(8)2561-2575(2018)
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