Background:
1-Palmitoyl-d9-2-palmitoyl-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.3 Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.4
1-Palmitoyl-d9-2-palmitoyl-sn-glycero-3-PC MaxSpec®sup>? standard is a quantitative grade standard of 1-palmitoyl-d9-2-palmitoyl-sn-glycero-3-PC that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 1-palmitoyl-d9-2-palmitoyl-sn-glycero-3-PC MaxSpec®sup>? standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
1.Ege, C., and Lee, K.Y.C.Insertion of Alzheimer's Aβ40 peptide into lipid monolayersBiophys. J.87(3)1732-1740(2004) 2.Leekumjorn, S., and Sum, A.K.Molecular simulation study of structural and dynamic properties of mixed DPPC/DPPE bilayersBiophys. J.90(11)3951-3965(2006) 3.Kalra, V.K., Sikka, S.C., and Sethi, G.S.Transport of amino acids in γ-glutamyl transpeptidase-implanted human erythrocytesJ. Biol. Chem.256(11)5567-5571(1981) 4.Uemura, A., Watarai, S., Iwasaki, T., et al.Induction of immune responses against glycosphingolipid antigens: Comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipidsJ. Vet. Med. Sci.67(12)1197-1201(2005)
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