Ac-QPKK(Ac)-AMC

A fluorogenic substrate for SIRT1, SIRT2, and SIRT3

原价

￥1212-19487

价格

￥ 970-15590

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库存: 现货

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产品引用

货号: ajcx23934
CAS: 1387005-23-3
别名: Ac-Gln-Pro-Lys-Lys-(Ac)-AMC, Ac-Gln-Pro-Lys-Lys-(Ac)-7-amino-4-methylcoumarin, p53317-320 Substrate (Ac-QPKK(Ac)-AMC)
分子式: C36H52N8O9
分子量: 740.9
纯度: >98%
溶解度: DMSO: soluble,Ethanol: soluble
储存: -20°C
库存: 现货

Background

Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3.¹ It is selectively deacylated by SIRT1-3 over SIRT6. Upon enzymatic cleavage by SIRT1, SIRT2, or SIRT3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify SIRT1, SIRT2, and SIRT3 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

1.Galleano, I., Schiedel, M., Jung, M., et al.A continuous, fluorogenic sirtuin 2 deacylase assay: Substrate screening and inhibitor evaluationJ. Med. Chem.59(3)1021-1031(2017)

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信号通路

生命科学

有机化学

无机化学

材料科学

Ac-QPKK(Ac)-AMC

Ac-QPKK(Ac)-AMC详情

Background