Heliquinomycin
A bacterial metabolite with diverse biological activities
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
1mg￥13187.0010550.00- +
- 货号: ajcx23944
- CAS: 178182-49-5
- 别名: NSC 702208, Rubymycin
- 分子式: C33H30O17
- 分子量: 698.6
- 纯度: ＞98%
- 溶解度:
- 储存: 4°C
- 库存: 现货
Background
Heliquinomycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It is active against a variety of Gram-positive bacteria, including strains of B. anthracis, B. subtilis, and methicillin-sensitive or -resistant S. aureus (MICs = <0.05-0.39 µg/ml). Heliquinomycin inhibits the activity of DNA helicase with a Ki value of 6.8 µM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 µg/ml, respectively).
1.Chino, M., Nishikawa, K., Umekita, M., et al.Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activitiesJ. Antibiot. (Tokyo)49(8)752-757(1996)
