Background:
Cholesteryl palmitate-d9 is intended for use as an internal standard for the quantification of cholesteryl palmitate by GC- or LC-MS. Cholesteryl palmitate is a cholesterol ester. It is a major cholesterol ester found in human meibum and has been used to form a stable tear film to study amphiphilic block copolymers as surfactants for dry eyes.1 Cholesteryl palmitate levels in amniotic fluid are decreased in pregnancies in which infants later developed respiratory distress syndrome and in patients with well-controlled diabetes.2,3 Levels of cholesteryl palmitate are increased in bronchoalveolar lavage fluid (BALF) from patients with chronic interstitial pneumonia.4
Cholesteryl palmitate-d9 MaxSpec®sup>? standard is a quantitative grade standard of cholesteryl palmitate-d9 that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This cholesteryl palmitate-d9 MaxSpec®sup>? standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.
1.Shine, W.E., and McCulley, J.P.Polar lipids in human meibomian gland secretionsCurr. Eye Res.26(2)89-94(2003) 2.Ludmir, J., Alvarez, J.G., Mennuti, M.T., et al.Cholesteryl palmitate as a predictor of fetal lung maturityAm. J. Obstet. Gynecol.157(1)84-88(1987) 3.Ludmir, J., Alvarez, J.G., Landon, M.B., et al.Amniotic fluid cholesteryl palmitate in pregnancies complicated by diabetes mellitusObstet. Gynecol.73(3 Pt.1)360-362(1988) 4.Fukuhara, N., Tachihara, M., Tanino, Y., et al.Cholesteryl palmitate crystals in bronchoalveolar lavage fluid smears as a possible prognostic biomarker for chronic interstitial pneumonia: A preliminary studyRespir. Investig.54(2)109-115(2016)
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