Aliskiren-d6 (hemifumarate)

An internal standard for the quantification of aliskiren

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库存: 现货

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1mg

￥20287.00

16230.00

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货号: ajcx23982
CAS: N/A
别名: CGP 60536 D6 hemifumarate; CGP60536B D6 hemifumarate; SPP 100 D6 hemifumarate
分子式: C30H47D6N3O6?1/2C4H4O4
分子量: 615.8
纯度: >98%
溶解度: DMSO: soluble,Methanol: soluble
储存: -20°C
库存: 现货

Background

Aliskiren-d₆ is intended for use as an internal standard for the quantification of aliskiren by GC- or LC-MS. Aliskiren is a nonpeptide inhibitor of renin (IC₅₀ = 0.6 nM for the human enzyme).¹ Aliskiren (10 and 30 mg/kg per day) reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes.² It also reduces cardiac hypertrophy and fibrosis induced by heart pressure overload in mice.³ Formulations containing aliskiren have been used in the treatment of hypertension.

1.Rhuel, R., Rasetti, V., Maibaum, J., et al.Structure-based drug design: The discovery of novel nonpeptide orally active inhibitors of human reninChem. Biol.7(7)493-504(2000) 2.Feldman, D.L., Jin, L., Xuan, H., et al.Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 ratsHypertension52(1)130-136(2008) 3.Weng, L., Zhang, W., Ye, Y., et al.Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in miceActa Pharmacol. Sin.35(8)1005-1014(2014)