A bacterial metabolite with antibacterial and anticancer activities
4'-Acetylchrysomycin B is a bacterial metabolite and derivative of chrysomycin B that has been found in Streptomyces and has antibacterial and anticancer activities.1 It is active against strains of B. subtilis, B. cereus, Corynebacterium bovis, and E. faecalis (MICs = 2-64 µg/ml). 4'-Acetylchrysomycin B is cytotoxic against a panel of human cancer cell lines, including doxorubicin-sensitive or -resistant cells (IC50s = 1.7-14 and 260-370 ng/ml, respectively).
1.Wada, S.-I., Sawa, R., Iwanami, F., et al.Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and BJ. Antibiot. (Tokyo)70(11)1078-1082(2017)
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