IMP-1700

An inhibitor of bacterial DNA repair

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库存: 现货

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5mg

￥1550.00

1240.00

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10mg

￥2650.00

2120.00

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25mg

￥6162.00

4930.00

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货号: ajcx24046
CAS: 1458674-25-3
别名:
分子式: C25H22F4N4O3S
分子量: 534.5
纯度: >98%
溶解度: DMF: slightly soluble,DMSO: slightly soluble
储存: -20°C
库存: 现货

Background

IMP-1700 is an inhibitor of bacterial DNA repair.¹ It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistant S. aureus (MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active against E. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC₅₀s = 0.5, 0.21, and 3.8 µM, respectively).

1.Lim, C.S.Q., Ha, K.P., Clarke, R.S., et al.Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureusBioorg. Med. Chem.27(20)114962(2019)