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- HDAC (Histone deacetylases)
- NR-160
NR-160
An inhibitor of HDAC6
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1337.001070.00- +
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5mg￥6000.004800.00- +
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10mg￥10675.008540.00- +
- 货号: ajcx24088
- CAS: 2484895-50-1
- 别名:
- 分子式: C25H21F3N6O3
- 分子量: 510.5
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml
- 储存: -20°C
- 库存: 现货
Background
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.03 µM).1 It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 µM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 µM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
1.Re?ing, N., S?nnichsen, M., Osko, J.D., et al.Multicomponent synthesis, binding mode, and structure-activity relationship of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groupsJ. Med. Chem.63(18)10339-10351(2020)
