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- Histone Methyltransferase
- Bisubstrate Inhibitor 78
Bisubstrate Inhibitor 78
An inhibitor of NNMT
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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500ug￥2800.002240.00- +
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1mg￥5275.004220.00- +
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5mg￥24700.0019760.00- +
- 货号: ajcx24094
- CAS: 2368247-39-4
- 别名:
- 分子式: C25H29N7O5
- 分子量: 507.5
- 纯度: ＞98%
- 溶解度: Chloroform: slightly soluble,DMF: slightly soluble,DMSO: slightly soluble,Ethanol: slightly soluble,Methanol: slightly soluble
- 储存: -20°C
- 库存: 现货
Background
Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50 = 1.41 µM).1 It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinamide . Bisubstrate inhibitor 78 is selective for NNMT over histone-lysine N-methytransferase NSD2 and protein arginine methyltransferase 1 (PRMT1; IC50s = >50 µM for both). It reduces levels of 1-methylnicotinamide in, and inhibits proliferation of, HSC-2 oral cancer cells when used at a concentration of 100 µM.
1.Gao, Y., van Haren, M.J., Moret, E.E., et al.Bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) with enhanced activityJ. Med. Chem.62(14)6597-6614(2019)
