Ac-DEVD-CHO (trifluoroacetate salt)

A dual caspase-3/caspase-7 inhibitor

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库存: 现货

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数量
500ug

￥737.00

590.00

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1mg

￥1250.00

1000.00

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5mg

￥4725.00

3780.00

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10mg

￥8725.00

6980.00

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货号: ajcx24108
CAS: N/A
别名: N-Ac-Asp-Glu-Val-Asp-CHO
分子式: C20H30N4O11?XCF3COOH
分子量: 502.5
纯度: >98%
溶解度: DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: -20°C
库存: 现货

Background

Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (K_is = 0.23 and 1.6 nM, respectively).^1,2 Notably, it also inhibits other caspases (K_is = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).¹ Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK , are irreversible.¹ Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.³

1.Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49)32608-32613(1998) 2.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9677-9682(1997) 3.Nicholson, D.W., Ali, A., Thornberry, N.A., et al.Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisNature37637-43(1995)