An internal standard for the quantification of cilnidipine
Cilnidipine-d7 is intended for use as an internal standard for the quantification of cilnidipine by GC- or LC-MS. Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM.1 Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats.2 It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg.3 Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.
1.Murai, Y., Uneyama, H., Ishibashi, H., et al.Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipineBrain Res.854(1-2)6-10(1999) 2.Hosono, M., Hiruma, T., Watanabe, K., et al.Inhibitory effect of cilnidipine on pressor response to acute cold stress in spontaneously hypertensive ratsJpn. J. Pharmacol.69(2)119-125(1995) 3.Takahara, A., Konda, T., Enomoto, A., et al.Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia modelBiol. Pharm. Bull.27(9)1388-1391(2004)
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