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A bacterial metabolite
Conglobatin C1 is a bacterial metabolite that has been found in Streptomyces MST-91080 and has anticancer activity.1 It is cytotoxic to NS-1 mouse myeloma cells (IC50 = 1.05 µg/ml) but not NFF human fibroblasts (IC50 = >100 µg/ml).
1.Lacey, H.J., Booth, T.J., Vuong, D., et al.Conglobatins B-E: Cytotoxic analogues of the C2-symmetric macrodiolide conglobatinJ. Antibiot. (Tokyo)73(11)756-765(2020)
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