Betulonaldehyde
A pentacyclic triterpenoid
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包装价格促销价数量
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10mg￥2662.002130.00- +
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50mg￥11250.009000.00- +
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100mg￥19687.0015750.00- +
- 货号: ajcx24206
- CAS: 4439-98-9
- 别名: 白桦脂醛,半合成
- 分子式: C30H46O2
- 分子量: 438.7
- 纯度: ＞98%
- 溶解度: DMF: 10 mg/ml
- 储存: -20°C
- 库存: 现货
Background
Betulonaldehyde is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin that has been found in Betula.1 It is active against P. falciparum (IC50 = 3.36 µg/ml) and cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s = 19.23 and 17.09 µg/ml, respectively).2 Topical application of betulonaldehyde (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate in mice.3 It has also been used a precursor in the semisynthesis of C-2 and C-28 betulonic aldehyde derivatives.1
1.Ayers, S., Benkovics, T., Marshall, J., et al.Autoxidation products of betulonaldehydeJ. Nat. Prod.79(10)2758-2761(2016) 2.Wisetsai, A., Schevenels, F.T., and Lekphrom, R.Chemical constituents and their biological activities from the roots of diospyros filipendulaNat. Prod. Res.1-5(2019) 3.Yasukawa, K., Yu, S., Yamanouchi, S., et al.Some lupane-type triterpenes inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skinPhytomedicine1(4)309-313(1995)
