Vanoxonin
A bacterial metabolite
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1mg￥10787.008630.00- +
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- 货号: ajcx24232
- CAS: 86933-99-5
- 别名: Antibiotic MG 245CF2A
- 分子式: C18H25N3O9
- 分子量: 427.4
- 纯度: ＞98%
- 溶解度:
- 储存: -20°C
- 库存: 现货
Background
Vanoxonin is a bacterial metabolite that has been found in S. hirsuta.1 It forms a complex with vanadium, and the complex inhibits thymidylate synthetase with an IC50 value of 0.7 µg/ml. The vanoxonin-vanadium complex is cytotoxic to L1210 leukemia cells (MIC = 25 µg/ml) and increases survival in Ehrlich murine spontaneous adenocarcinoma and L1210 mouse tumor models.
1.Kanai, F., Sawa, T., Hamada, M., et al.Vanoxonin, a new inhibitor of thymidylate synthetaseJ. Antibiot. (Tokyo)36(6)656-660(1983)
