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- HDAC (Histone deacetylases)
- Panobinostat-d4 (hydrochloride)
Panobinostat-d4 (hydrochloride)
An internal standard for the quantification of panobinostat
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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500ug￥1625.001300.00- +
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1mg￥2775.002220.00- +
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5mg￥12837.0010270.00- +
- 货号: ajcx24340
- CAS: N/A
- 别名: LBH589-d4 hydrochloride; NVP-LBH589-d4 hydrochloride
- 分子式: C21H19D4N3O2?HCl
- 分子量: 389.9
- 纯度: ＞98%
- 溶解度: DMSO: soluble,Methanol: soluble
- 储存: -20°C
- 库存: 现货
Background
Panobinostat-d4 (hydrochloride) is intended for use as an internal standard for the quantification of panobinostat by GC- or LC-MS. Panobinostat is a pan-inhibitor of histone deacetylases (HDACs; Kis = 0.6-31 nM for HDAC1-11).1 It inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and mesothelioma cancer cells (IC50s = 4-175, 5-310, and 5-470 nM, respectively), but not NCI H661 mouse NSCLC cells (IC50 = >800 nM).2 Panobinostat (20 mg/kg, i.p.) induces tumor regression in BK-T and RG-1 SCLC mouse xenograft models.
1.Wang, H., Yu, N., Chen, D., et al.Discovery of (2E)-3-{2-butyl-1-[2-diethylamino)ethyl]-1H-benzamidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profileJ. Med. Chem.54(13)4694-4720(2011) 2.Crisanti, M.C., Wallace, A.F., Kapoor, V., et al.The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancerMol. Cancer Ther.8(8)2221-2231(2009)
