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- Lornoxicam-d4
Lornoxicam-d4
An internal standard for the quantification of lornoxicam
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1012.00810.00- +
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5mg￥4012.003210.00- +
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10mg￥7550.006040.00- +
- 货号: ajcx24394
- CAS: 1216527-48-8
- 别名: 氯诺昔康-D4,Chlortenoxicam-d4; Ro 13-9297-d4
- 分子式: C13H6ClD4N3O4S2
- 分子量: 375.8
- 纯度: ＞98%
- 溶解度: DMSO: 2 mg/ml
- 储存: -20°C
- 库存: 现货
Background
Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.1 It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells (IC50 = 3 nM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells (IC50 = 8 nM), which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg.2 Formulations containing lornoxicam have been used in the management of postoperative pain.
1.Berg, J., Fellier, H., Christoph, T., et al.The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitroInflamm. Res.48(7)369-379(1999) 2.Buritova, J., and Besson, J.M.Potent anti-inflammatory/analgesic effects of lornoxicam in comparison to other nsaids: A c-Fos study in the ratInflammopharmacology5(4)331-341(1997)
